Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations
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چکیده
منابع مشابه
Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar Concentrations
In Alzheimer's disease (AD), tau aggregates into fibrils and higher order neurofibrillary tangles, a key histopathological feature of AD. However, soluble oligomeric tau species may play a more critical role in AD progression since these tau species correlate better with neuronal loss and cognitive dysfunction. Recent studies show that extracellular oligomeric tau can inhibit memory formation a...
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ژورنال
عنوان ژورنال: International Journal of Cell Biology
سال: 2013
ISSN: 1687-8876,1687-8884
DOI: 10.1155/2013/260787